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Formatting a Numbers in DataFrame

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Can someone please help me to format just numbers in a data frame to "int" and "comma"? I tried doing the same and got an error message mentioned below.

Error: int() argument must be string, a bytes-like object or a number, not 'DataFrame'

import pandas as pddata1 = {'Header':['L1','L2','L3'], 'Val1':[float(1000.2),float(2000.40),float(300.55)],'Val2':[float(4000.3),float(500.00),float(60000.55)]}

The expected output is mentioned below.

HeaderVal1Val2
L11,0004,000
L22,000500
L330160,001

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